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In 1994, Pfizer scientists ascertained that sildenafil, which as well inhibits the PDE5 enzyme, caused penile hard-on in males participating in a clinical meditate of a eye medical specialty. Although ICOS scientists were not testing heighten IC351 for treating ED, they recognised its potential difference usefulness for treating that disarray. Soon, in 1994, ICOS received a patent of invention for compound IC351 (structurally unequal sildenafil citrate and vardenafil), and Phase angle 1 clinical trials began in 1995.
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